I would say that if you're even semi-confident you will not be "Re-Organized" after moving, then GO FOR IT! I have transplanted several times, and each time I have been glad I did. Sure, there are a lot of people/places/activities left behind, but I find a new perspective on the world very refreshing every 10 years or so.

I have been through WV a few times, very beautiful part of the world... at least the view from the turnpike.